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Marola M, Rodrigues CE

This method avoids first-pass metabolism, which can enhance bioavailability compared to traditional delivery methods

[DOI] [PubMed] [Google Scholar] 95.Kumar A., Singh B.K., Ahmad I., Shukla S., Patel D.K., Srivastava G., Kumar V., Pandey H.P., Singh C

Serious complications are rare, though infection, allergic reactions, or unintended tissue injury are possible

Moreover, hyperinsulinemia, a phenomenon associated with insulin resistance, results in high levels of insulin and glucose in blood, leading to an increase in the release of proinflammatory cytokines, promoting microglial proliferation and proinflammatory polarization in vivo (Yang et al., 2022)

It is important to note that pyroptosome is not necessary for the execution of pyroptosis, which can occur by NLRC4 dependent Caspase-1 activation [92]